Booka Shade, Laurent Garnier, James Zabiela and M.A.N.D.Y. are also confirmed for event in London next April.
Leftfield will headline a charity event at O2 Academy Brixton on April 21st.
Proceeds from the event will go to War Child, an organization that helps children affected by conflicts in Afghanistan, Iraq, Democratic Republic of Congo and Uganda among other places. In addition to Leftield, a veteran UK group that now consists solely of Neil Barnes, the lineup will feature Booka Shade, who will play live, and M.A.N.D.Y., their partners in crime at Get Physical Music in Berlin. Other big names include Laurent Garnier and tech house heavyweight James Zabiela. The event is co-hosted by Red Bull Studios London.